Gyrolab xPlore applications:
(1) Pharmacokinetics (PK); Toxicokinetics (TK);
(2) Immunogenicity analysis; Anti-drug antibody (ADA) detection;
(3) Pharmacodynamics (PD); Detection of biomarkers;
(4) Production process IgG titer and impurity detection (HCP, Protein A)
(5) Affinity testing, vaccine research...
Gyrolab xPlore system, which adopts automatic sampling mode, combines the traditional double antibody sandwich macromolecule detection method with the patented microfluidic CD technology perfectly. It can achieve the experimental results that other experimental methods need manual operation can not achieve, including perfect data repeatability, high detection sensitivity, ultra-wide detection range and strong anti-matrix effect ability. Minimum sample size, etc.
Figure 1: Diagram of microfluidic CD
The characteristics of Gyrolab xPlore technology are as follows:
(1) Save time:
Sample analysis (sampling, cleaning, data processing) of a CD was completed in one hour, and new experiments were developed in a few days instead of a few weeks.
(2) Low sample size:
Microfluidic technology, nano-upgrade sampling (minimum sample size 20 nl); a mouse can make a complete PK curve, saving experimental animals;
(3) High flux:
Each CD has 112 data points, one CD can be made in each batch.
(4) The detection range is wide:
Widening LLOQ and ULOQ, perfectly covering samples of different concentration ranges;
(5) Low matrix effect:
For any sample matrix, MRD can be reduced by 2 times.
(6) Fully automatic:
Sampling, reagent addition, cleaning and testing are all fully automated. To avoid human errors and reduce CV value, overnight experiments can be conducted to improve the flux.
(7) High sensitivity:
Pg / mL level of high sensitivity, easy detection of low concentration samples;
(8) High precision and good repeatability:
Different people, laboratories and companies can get consistent results, improve the success rate and reduce the repetition of experiments.
Figure 2: Comparisons between Gyrolab and ELISA
Figure 3: Comparison of detection ranges between Gyrolab and ELISA techniques
At the same time, the result analysis software Evaluator of Gyrolab xPlore supports automatic curve fitting, output of parameter results and other functions, and also supports the export of results to LIMS system. The software meets the requirements of Federal Regulation 21 CFR Part 11 and provides extensive verification support.
These characteristics and advantages liberate the hands of the experimenter, so that the experimenter can complete the method development, method validation and sample detection experiments in the shortest time with the least amount of samples, and get the best data. Thus, the data that can be used for decision-making can be obtained more quickly and easily, so as to promote drug research and development to enter the next step faster and to market as soon as possible.
These advantages make Gyrolab platform become the world's major well-known pharmaceutical companies, CRO companies including Pfizer, Novartis, Amgen, AstraZeneca, Roche, Sanofi, Lilai and other major macromolecule research and development platforms, has become one of the mainstream devices for future macromolecule drug research and development. If you want to keep up with the world's mainstream research and development technology trends, you might as well learn about this powerful experimental platform. !