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Why store immune cells?

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Why store immune cells?

Date of release:2018-06-21 Author: Click:

Why store immune cells? Leukocyte storage can greatly contribute to people's health, can play an important role in the critical moment, the following Jinan cell engineering to introduce you


Living cells


Immune cells, commonly known as white blood cells, are responsible for immune surveillance, immune defense and immune homeostasis.(Living cells

The quantity and quality of immune cells are closely related to health. However, they will gradually decrease with age. And diet, air, mental stress and other external factors can also cause the number and quality of immune cells decline. The increasing aging and high incidence of tumors in humans is a good indication that the health of our immune cells is being seriously threatened.
In the 21st century, the World Health Organization has made a more scientific definition of disease rehabilitation: the most fundamental way to cure disease is to repair cells, improve cell metabolism, and activate cell function.

However, a large number of clinical trials have shown that the quality of immune cells used in the treatment process directly affects the effectiveness of clinical treatment. Therefore, the storage of young and active immune cells, the need for future use, is not only a guarantee of their own lives, but also for the development of immunotherapy technology has great significance.
Is cryopreservation technology mature?

In 1985, Rail and Fahy succeeded in vitrifying mouse embryos with this vitrification solution, which was the first breakthrough in the practical application of biological cryopreservation technology. After decades of development, cryopreservation technology has become a widely used technology in scientific research and clinical research.

In 2016, the Long March prototype automatic biological sample library was opened, which is the first integrated automatic biological sample library in China - 80 C. This indicates that China's biological cryopreservation has begun to get rid of the bottleneck of manual operation of traditional sample storage and stepped into the era of automatic storage.
In 2017, the Long March Hospital and the Atomic Cells restarted the full-automatic cryogenic cell repository, allowing this automation process to take a step further, achieving full-automatic cell access at - 196 degrees Celsius.
It can be said that today's cell access technology has fully prepared for the advent of the era of cell therapy.
How to choose cell bank?

Cells can be said to be the most important strategic reserves of our lives. So the institutions that choose to store must be cautious. How to find a safe haven for your cell, 3 factors must be considered.

1. storage conditions, including cryopreservation technology and storage devices.
As the temperature decreases, water inside and outside the cell freezes, resulting in ice crystals that destroy cell membranes and organelles and cause cell death. Therefore, the cooling process of cells must be extremely slow and accurate. The cooling conditions of each cell need different conditions. Therefore, cryopreservation techniques for different cell types play a decisive role in the results of different cell cryopreservation. The cryogenic Laboratory of protoplasmic cells, built with Professor Gao Dayong of the University of Washington, is a guarantee of the safety of cell storage.
In addition, cell viability and cell quality will be directly affected by the tremendous vibration and temperature changes during freezing. Secondly, the accuracy of cell related information is also a crucial step in cell storage. This is also a bottleneck that traditional storage methods have never been able to break through. The emergence of automated storage has successfully broken through these obstacles.
       2. storage process
Cell storage process generally includes cell collection, transportation, preparation before storage, cell cryopreservation and late cell recovery. Whether every link has strict standard quality control process is the key factor affecting the subsequent application.
In addition, in addition to physical examination before collection, precise and rigorous sample testing before storage can not only ensure the survival rate of cells after storage, but also ensure the safety of all cells in the library. This can not be ignored when choosing storage agencies.
       3. background of storage mechanism
Anyone who has paid close attention to the changes in the market for the storage of immune cells before and after the Weizexi Incident is keenly aware of this.
Before the outbreak of the Weizexi Incident in 2015, there were more than 100 companies of all sizes in Zhangjiang area to store or treat immune cells. After that, in this industry shuffle, countless enterprises shut down or changed careers. Looking back today, most of the enterprises that can still stand on the front line of the industry are either listed companies or supported by large consortia. It can be seen that in order to go a long way in this industry, resources and funds are indispensable except for standardized operation.
What areas can stored immune cells be used in?
Most experts in medicine and science think that more than 90% of diseases are related to immunity. The dominant role of immune cells in the realization of immune function and the elimination of aging cells makes it one of the popular means to improve sub-health and postpone human aging.
At present, immune cells are mainly used in the treatment of cancer, viral infection and so on. Cancer tumors include lymphoma, breast cancer, cervical cancer, liver cancer and so on. There are many successful cases in clinic. Immunocyte therapy is an effective means to prevent tumor recurrence or metastasis, and can improve the prognosis and survival quality of patients. Increase the body immunity, significantly prolong the overall survival and progression free survival. The treatment has high safety, mild adverse reactions and few serious adverse events. However, good immune cells are one of the key factors in the efficiency and outcome of treatment. If the immune cells are not good, the therapeutic effect will be discounted.
The world's first Emily, who received CAR-T therapy, relapsed after 16 months of chemotherapy. She began to pick up in April 2012.


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Key word:Livingcells,Cellanalysistechnology,cellengineering

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